[Skip to Content]
[Skip to Content Landing]
Article
January 1941

TIME-ACTIVITY CURVES OF PROTAMINE ZINC INSULINCLINICAL APPLICATION AND SIGNIFICANCE OF SUCH CURVES IN THE TREATMENT OF PATIENTS WITH SEVERE DIABETES

Arch Intern Med (Chic). 1941;67(1):194-206. doi:10.1001/archinte.1941.00200010204012
Abstract

Among the roles played by insulin in carbohydrate metabolism, two have been stressed in previous publications from this laboratory.1 These roles may be summarized briefly as follows: (1) the control of new sugar formation in the fasting state, taken care of by the "basal insulin," and (2) the dextrose-disposing mechanism of insulin, operating by oxidation or storage.

It has been shown by many observers that the depancreatized dog in the fasting state has a high blood sugar level. The maintenance of a constant normal blood sugar level in the fasting diabetic dog requires the intravenous injection of insulin at the rate of 0.0051 to 0.035 unit per kilogram per hour, as shown by Greeleyla and Houssay.2 Evidence that certain patients with severe diabetes may also have a rising blood sugar level in the fasting state has been reported by Martin, Drury and Strouse.1c They showed that

First Page Preview View Large
First page PDF preview
First page PDF preview
×