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Article
February 1941

PNEUMOCOCCIC PNEUMONIA: AN ANALYSIS OF THE RECORDS OF 1,469 PATIENTS TREATED IN THE LOS ANGELES COUNTY HOSPITAL FROM 1934 TO 1938 INCLUSIVE III. TYPE-SPECIFIC ANTIPNEUMOCOCCUS SERUM THERAPY: QUANTITATIVE RELATIONS BETWEEN DOSAGE AND RESULTS

Arch Intern Med (Chic). 1941;67(2):286-303. doi:10.1001/archinte.1941.00200020048003
Abstract

Treatment of pneumococcic pneumonia with type-specific antipneumococcus serum has received wide attention.1 "Adequate" treatment is said to hasten recovery and improve the outcome. Three major factors determine the "adequacy" of serum: the duration of the untreated disease, the total amount of serum given and the rapidity of its administration. It is reasonable that these factors are interdependent in such a way that the relations between them are quantitative and amenable to analysis.

MATERIALS AND METHODS2  In the preceding articles3 certain data have been presented concerning all (1,469) patients with typed pneumococcic pneumonia treated in the Los Angeles County Hospital during the five year period 1934 to 1938. Of these, 569 received specific serum therapy, but 56 cases were discarded because the records were inadequate. The remaining 513 are otherwise unselected.All patients received commercial type-specific, horse or rabbit antipneumococcus serum intravenously, in various hospital services, at the order

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