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Article
February 1941

ESTIMATION OF RENAL FUNCTION WITH THE AID OF AN IODOSECRETORY INDEX AND A NEW UREOSECRETORY INDEX: AN IMPROVED APPLICATION OF THE CREATININE METHOD FOR DETERMINING DIURESIS

Author Affiliations

Privatdocent at the University of Leyden; Chief Physician of Clinics for Internal Diseases in The Hague and Haarlem (Netherlands) NEW YORK

Arch Intern Med (Chic). 1941;67(2):345-371. doi:10.1001/archinte.1941.00200020107007
Abstract

It is the object of the examinations and observations described in this article to obtain more accurate results in the estimation of renal function.

For this purpose it is recommended to use an iodosecretory index, obtained after administering an iodide. Should this not be possible or not be allowed, it is advised to replace this iodosecretory index by a new ureosecretory index. Both indexes have been deduced from the improved laws of Ambard, and the manner in which this has been done is described.

In 1919 I described a formula for the application of Ambard's laws in the diagnosis of renal diseases. This formula had certain advantages over the formula deduced by Ambard himself from his laws.1 It appeared, however, that the new formula was endowed with some hereditary taint, for in 1921 Austin, Stillman and Van Slyke,2 examiners at the Rockefeller Institute of New York, established the

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