It is universally recognized that liver therapy produces beneficial effects when administered to patients suffering from pernicious anemia. The efficacy of this form of treatment in the improvement of the neurologic signs and symptoms in subacute combined degeneration of the spinal cord was questioned when administration of liver was first instituted as a therapeutic measure for this disorder. During the early period of its use, most observers stated the belief that the improvement was limited to the subjective neurologic symptoms and that the objective signs remained unchanged. This opinion was, however, gradually changed because of the numerous reports by Richardson;1 Ungley and Suzman;2 Needles;3 Minot and Murphy;4 Baker, Bordley and Longcope;5 Strauss, Solomon, Schneider and Patek;6 Hyland and Farquharson,7 and others, who demonstrated improvement in the objective neurologic signs in those patients who received adequate amounts of liver. Despite these findings, a certain amount of skepticism
DAVISON C. EFFECT OF LIVER THERAPY ON PATHWAYS OF SPINAL CORD IN SUBACUTE COMBINED DEGENERATION. Arch Intern Med (Chic). 1941;67(3):473–488. doi:10.1001/archinte.1941.00200030003001
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