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Article
April 1941

PRECOCIOUS PUBERTY AND TUMORS OF THE HYPOTHALAMUSREPORT OF A CASE AND REVIEW OF THE LITERATURE, WITH A PATHOPHYSIOLOGIC EXPLANATION OF THE PRECOCIOUS SEXUAL SYNDROME

Arch Intern Med (Chic). 1941;67(4):762-792. doi:10.1001/archinte.1941.00200040055005
Abstract

Though numerous endocrine disturbances occur with disease or tumors of the brain, none has a more intriguing interest or presents so challenging a problem with respect to its cause than precocious puberty.

There is at present a widely believed theory that it is caused in some way by tumors of, or in the region of, the pineal body. This association was first pointed out by Gutzeit,1 but his case, viewed now, curiously does not appear to be a genuine instance of precocious puberty. The clinical and diagnostic features of "pinealism" were described by Frankl-Hochwart,2 who wrote:

When one finds in a very young person (boy) along with the general symptoms of tumor, as well as the local signs of a lesion of the corpora quadrigemina, abnormal body growth, unusual growth of hair, adiposity, somnolence, premature genital and sexual development and, finally, intellectual maturity, one must think of a

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