Thirty-two members of 7 white families having osteogenesis imperfecta have been found to reside in or near Washington, D. C.1 In 5 of the families there is a definite hereditary tendency, while in the other 2 families with no such tendency the disease is represented in its isolated form. The ascendants, descendants and collaterals of the various families were studied, and 91 cases of the disease were found in a total of 255 members. Seven generations of 1 family, six generations of 2 families and five generations of another family were traced. The origin of the condition in 1 of the family groups was in Ireland, in 1790; in 2 family groups, in Germany, 1 in 1735 and the other in 1770, and the remaining 4, in this country, 2 in Virginia, dating back to 1808 and 1896, and the other 2 in the District of Columbia.
F. REGIS RIESENMAN, WALLACE M. YATER. OSTEOGENESIS IMPERFECTAITS INCIDENCE AND MANIFESTATIONS IN SEVEN FAMILIES. Arch Intern Med (Chic). 1941;67(5):950–967. doi:10.1001/archinte.1941.00200050058005