Since the introduction of chemical analysis of blood in the investigation of renal disease and the use of tests of renal function, true uremia is considered as poisoning due to retention in the blood of urinary waste products. Almost every urinary constituent has been considered as the basic substance which causes the clinical symptoms displayed by patients with uremia. The attempt, however, to hold a single "uremia toxin" responsible for the clinical picture of uremia has failed. No single substance has been discovered the retention of which, as a result of renal insufficiency, produces uremia. The concept prevailing now (Volhard,1 Fishberg2 and Harrison and Mason3) has been clearly expressed by Fishberg: "Uremia is a complex autointoxication, the variegated clinical picture being the summation of the effects of retention of various urinary constituents." The most important substances which are considered as playing a role in the production of
RACHMILEWITZ M. EFFECT OF UREMIC SERUM AND URINE ON GROWTH OF FIBROBLASTS IN VITRO. Arch Intern Med (Chic). 1941;67(6):1132–1143. doi:10.1001/archinte.1941.00200060035005
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