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Article
July 1941

METABOLISM AND DIABETES: REVIEW OF CERTAIN RECENT CONTRIBUTIONS

Author Affiliations

Fellow in Medicine, the Mayo Foundation ROCHESTER, MINN.

From the Division of Medicine (Dr. Rynearson), the Mayo Clinic.

Arch Intern Med (Chic). 1941;68(1):134-175. doi:10.1001/archinte.1941.00200070144010
Abstract

GLYCOGEN AND CARBOHYDRATE METABOLISM  In last year's review the importance of the work of Cori and his associates1 on the synthesis of glycogen in vitro by the action of an enzyme called phosphorylase was pointed out. Phosphorylase, which is found in liver and muscle extracts and in yeast, acts on dextrose and phosphoric acid in the presence of adenylic acid, which acts as a coenzyme. Cori proceeded further in this investigation and in a recent paper2 outlined the steps in the metabolism of glycogen as follows: 1. Glycogen plus phosphoric acid in the presence of the glycogen phosphorylase found in liver and other tissue yields dextrose-1-phosphate. This is a reversible reaction. 2. Dextrose-1-phosphate in the presence of phosphoglucomutase, an enzyme which is found in all tissue extracts, yields dextrose-6-phosphate. This reaction is irreversible. 3. Dextrose-6-phosphate in the presence of isomerase, an enzyme which is found in all tissue

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