The mortality rate from pneumococcic meningitis was practically 100 per cent previous to 1937. Goldstein and Goldstein1 in a review of the literature up to 1927 collected only 150 authentic reports of recovery from this disease. Of a series of 468 patients with bacterial meningitis admitted to the State Charity Hospital of Louisiana in the ten year period prior to 1936, Tripoli2 reported that illness in 111 was due to pneumococci and that 110 died, a mortality rate of 99 per cent. Toomey and Roach3 reported that 157 patients with pneumococcic meningitis were admitted to the Cleveland City Hospital between 1922 and 1939 and that they all died irrespective of treatment.
When effective concentrated type-specific antipneumococcus horse serum became available about 1930, the antibodies were used in an attempt to treat pneumococcic meningitis. That the results were disappointing was shown by the fact that the Quarterly Cumulative
STEELE CW, GOTTLIEB J. TREATMENT OF PNEUMOCOCCIC MENINGITIS WITH SULFANILAMIDE AND SULFAPYRIDINE: STATISTICAL STUDY OF ALL REPORTED CASES IN WHICH CHEMOTHERAPY WAS USED, WITH OR WITHOUT SPECIFIC ANTIPNEUMOCOCCUS SERUM. Arch Intern Med (Chic). 1941;68(2):211–231. doi:10.1001/archinte.1941.00200080033003
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