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Article
September 1941

ACACIA IN TREATMENT OF THE NEPHROTIC SYNDROME: WITH SPECIAL REFERENCE TO EXCRETION OF CHLORIDE AND WATER; A REPORT OF CASES

Author Affiliations

PHILADELPHIA; ROCHESTER, MINN.

From the Division of Medicine, the Mayo Clinic (Dr. Keith and Dr. Binger).

Arch Intern Med (Chic). 1941;68(3):513-524. doi:10.1001/archinte.1941.00200090140006
Abstract

Elsewhere1 two of us (A. G. and M. W. B.) have summarized our clinical experience with acacia in the treatment of nephrotic edema. In a consecutive series of 40 patients it was found that 36, or 90 per cent, could be relieved of edema when they followed a regimen of diet, ingestion of potassium nitrate and injections of acacia.

The reason acacia originally was administered is obvious. It was thought that injections of solutions of this colloid material would increase the colloid osmotic pressure of the serum in cases of nephrotic edema and thus facilitate the reabsorption of the fluid resulting from edema. However, actual determination of colloid osmotic pressure before and after a therapeutic course of injections of acacia did not reveal consistent differences. Goudsmit, Binger and Power2 found that after completion of a course of injections of acacia the colloid osmotic pressure in 43 per cent

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