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Article
October 1941

ACACIA IN THE TREATMENT OF THE NEPHROTIC SYNDROME: INFLUENCE OF ACACIA, INJECTED INTRAVENOUSLY, ON CONCENTRATION OF PROTEINS AND ON COLLOID OSMOTIC PRESSURE OF THE SERUM

Arch Intern Med (Chic). 1941;68(4):701-712. doi:10.1001/archinte.1941.00200100040004
Abstract

The intravenous administration of solution of acacia to patients with a nephrotic type of edema is being employed by many physicians. Two of us (Goudsmit and Binger1) recently reviewed the literature on such treatment and reported experiences with this therapeutic adjunct in 40 cases, in 36 of which the patients were effectively and rapidly relieved of their edema. No harmful effects were noticed.

It has been tacitly assumed by most investigators that the colloid osmotic pressure of the serum is increased after the introduction into the blood stream of quantities of acacia such as were employed with favorable results. Indeed, Kerkhof2 reported 1 case in which there was extensive nephrotic edema and the serum exerted a colloid osmotic pressure of 8 mm. of mercury (109 mm. of water). Three hundred grams of acacia in 30 per cent solution was given in the course of three days. One hour

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