Since one of us (E. J. K.)1 reviewed for this journal the literature dealing with the diseases of the adrenal glands remarkable progress has been made. Crystalline compounds of known chemical structure have been isolated from the adrenal cortex, and one of these subsequently has been synthesized. The pharmacologic properties of many of these substances have been delineated in detail. As a result the treatment of Addison's disease has improved greatly. Better methods for the recognition of Addison's disease have been developed. The ramifications of the physiologic abnormalities of adrenal cortical insufficiency have been explored further. Knowledge of the relation of the adrenal cortex to the constellation of physiologic processes which pertain to sex has been materially advanced, and, in addition, many experimental studies which are concerned with "interglandular relations" have been conducted. Finally, the therapeutic potentialities of adrenal cortical substances for the treatment of disorders which are not
KEPLER EJ, WILLSON DM. DISEASES OF THE ADRENAL GLANDS: I. ADDISON'S DISEASE. Arch Intern Med (Chic). 1941;68(5):979–1009. doi:10.1001/archinte.1941.00200110131008
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