As early as 1844 von Rokitansky1 noted the rarity of tubercles in the hypophysis. Both Anderson2 and Scott and Graves3 (in a review of the literature to 1933) found no recorded cases of tuberculoma of the hypophysis in the literature. Certain authors4 failed to mention the existence of tuberculous involvement of this endocrine gland, while others5 concurred in the opinion that it was rare. Garland and Armitage,6 in examining 3,533 brains post mortem, found that only 2 of 89 intracranial tuberculomas involved the sella turcica. Falta7 mentioned that von Frankl-Hochwart found 7 instances of a tubercle in 97 cases of tumor of the hypophysis without acromegaly. Houssay8 stated that "circumscribed tuberculous lesions affecting the pituitary as well as metastatic lesions from distant foci and invasion from neighboring tissues have been described," and listed twenty-one references to the literature. Simonds9 was able to collect records of 28 instances
KIRSHBAUM JD, LEVY HA. TUBERCULOMA OF HYPOPHYSIS WITH INSUFFICIENCY OF ANTERIOR LOBEA CLINICAL AND PATHOLOGIC STUDY OF TWO CASES. Arch Intern Med (Chic). 1941;68(6):1095–1104. doi:10.1001/archinte.1941.00200120054004
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