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Article
April 1942

RENAL LESIONS FOLLOWING THE INTRAVENOUS INJECTION OF A HYPERTONIC SOLUTION OF SUCROSE: A CLINICAL AND EXPERIMENTAL STUDY

Author Affiliations

MEMPHIS, TENN.

From the Department of Pathology, University of Tennessee.

Arch Intern Med (Chic). 1942;69(4):670-690. doi:10.1001/archinte.1942.00200160121010
Abstract

Sucrose has been widely used for tissue dehydration in such conditions as cerebral edema associated with trauma,1 chronic hypertension,2 acute alcoholism,3 status asthmaticus,4 postoperative anemia,5 edema of nephrosis and nutritional edema.6

The quantity and the concentration of sucrose given to patients have varied widely. Dyar and Matthew7 gave 400 cc. of a 25 per cent solution intravenously. These investigators found no contraindication to the use of sucrose except perhaps the presence of markedly low renal function. Masserman8 has given intravenously as much as 500 cc. of a 50 per cent solution of sucrose. He expressed the opinion that "comparatively large amounts of sucrose in the circulation are not toxic and cause no serious disturbances in the chemistry or cytology of the blood." Keith and Power9 found "the total excretion of the various urinary constituents during a day in which sucrose is injected but slightly altered aside from

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