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Article
May 1942

NEOARSPHENAMINE THERAPY OF BACTERIAL INFECTIONS: WITH A METHOD OF ADMINISTRATION TO MAINTAIN UNIFORM BLOOD LEVELS FOR THE TREATMENT OF SERIOUS STAPHYLOCOCCIC INFECTIONS AND SUBACUTE BACTERIAL ENDOCARDITIS

Author Affiliations

PORTLAND, ORE.

From the Department of Medicine and the Division of Experimental Medicine, University of Oregon Medical School.

Arch Intern Med (Chic). 1942;69(5):746-765. doi:10.1001/archinte.1942.00200170028003
Abstract

Neoarsphenamine has been widely used in the therapy of syphilis since the synthesis of the drug by Ehrlich, but it has received relatively little attention as a chemotherapeutic agent against other bacterial infections. Reports by E. LeCocq1 and J. LeCocq2 of its effectiveness in the treatment of serious staphylococcic infections led to experimental3 and clinical4 confirmation of its effectiveness against staphylococci. This paper summarizes results of studies in progress, details of which were presented in an exhibit at the 1941 session of the American Medical Association and will appear in subsequent publications. It is hoped that this summary will stimulate further investigation of neoarsphenamine and related compounds as chemotherapeutic agents against bacterial infections.

In previous publications,3 by use of the marrow culture technic, which permits controlled quantitative studies of the effectiveness of chemotherapeutic agents against bacterial infections in the presence of living human cells, it

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