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Article
September 1942

CONGO RED TEST FOR AMYLOID DISEASE: A QUANTITATIVE TECHNIC

Author Affiliations

SAYRE, PA.; CHICAGO

From the Department of Surgery, Division of Orthopedic Surgery, the University of Chicago.

Arch Intern Med (Chic). 1942;70(3):416-420. doi:10.1001/archinte.1942.00200210071005
Abstract

Prior to the demonstration by Bennhold1 that a diagnosis of amyloid disease could be based on the selective affinity of deposits of this substance within the body, any decision as to the presence of amyloid deposits in the body rested on presumptive data. In another article we2 have presented cases that we have encountered in which this test was of service in arriving at a diagnosis. Even our restricted data demonstrate the utility of this little known test. Bennhold's original technic of the injection of 10 cc. of a 1 per cent congo red solution has been used since his method first appeared.3 While our work was in progress Friedman and Auerbach4 and later Taran5 eliminated the factor of possible hemolysis by precipitating proteins with alcohol and (according to Taran) with acetone.

METHOD 

Technic.  —We have made several modifications and refinements in the technic of

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