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October 1942


Author Affiliations


From the Department of Medicine, Stanford University School of Medicine.

Arch Intern Med (Chic). 1942;70(4):532-557. doi:10.1001/archinte.1942.00200220022003

The existence of a dietary factor, an absence of which will cause superficial gastric ulcers in chicks, is well recognized by persons interested in the nutrition of poultry.1 Members of the medical profession at large hardly seem aware of this factor and of the significant fact that definite gastric lesions may be produced experimentally, at least in chicks, by dietary means alone. Of perhaps even greater significance is the recent demonstration that the same type of erosive lesion may be produced by feeding cinchophen, which will cause not only superficial ulcers but the severer types of gastric ulceration encountered in man, including deep penetration and perforation.2 These cinchophen gastric ulcers differ only in degree from ulcers produced by a deficient diet alone, and they may also be prevented or modified by a dietary factor.

As this important relation exists between these two apparently etiologically different types of experimentally

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