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Article
November 1942

SULFONAMIDE COMPOUNDS IN THERAPY OF BACTERIAL ENDOCARDITIS: A COMPARISON OF THE IN VITRO INHIBITORY EFFECTS AND THE BACTERIOSTATIC ACTIVITY

Author Affiliations

DURHAM, N. C.

From the Departments of Medicine and Bacteriology, Duke University School of Medicine and Duke Hospital.

Arch Intern Med (Chic). 1942;70(5):777-784. doi:10.1001/archinte.1942.00200230090007
Abstract

Since the introduction of sulfonamide compounds into clinical medicine new interest has been awakened in the chemotherapy of bacterial endocarditis. In recent years the clinical effectiveness of these compounds has been demonstrated1 in a small yet hopeful number of patients suffering from this generally fatal disease. In a previous communication2 considerable variability was noted in the inhibitory effects in vitro of sulfonamide compounds on the growth of certain organisms isolated from human beings with bacterial endocarditis. The preliminary subjecting of each organism to the reaction of the several drugs in vitro prior to the institution of therapy would seem to be a rational and important procedure, provided that in vitro inhibition can be correlated with clinical bacteriostatic activity. Opinion with regard to the degree of correlation of in vitro and in vivo (animal experiments) studies is divided.3 Long and Bliss4 expressed the belief that there is

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