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March 1943


Author Affiliations


From the Research Service, First (Columbia) Division, Goldwater Memorial Hospital, and the Department of Medicine, College of Physicians and Surgeons, Columbia University.

Arch Intern Med (Chic). 1943;71(3):397-402. doi:10.1001/archinte.1943.00210030098009

Previous studies1 have demonstrated an apparent constancy of the serum cholesterol level in normal persons during long periods of observation. It is therefore considered of interest to determine whether or not the serum cholesterol level in patients with coronary arteriosclerosis behaves in a similar manner.

The literature on this subject is not conclusive, and it is based on single determinations of the blood cholesterol in varying numbers of subjects, arbitrarily designated as arteriosclerotic persons and normal controls. From a study of 13 patients with arteriosclerosis and 9 normal persons, Bachmeister and Henes,2 in 1913, concluded that patients with arteriosclerosis in the stage of development showed an increase in blood cholesterol. In the same year Weltmann3 reported that 11 of 12 persons with arteriosclerosis had increased blood cholesterol. Denis,4 in 1917, found that 5 of 14 patients with arteriosclerosis had values for blood cholesterol that exceeded those