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April 1943

The Antigonadotropic Factor, with Consideration of the Antihormone Problem.

Arch Intern Med (Chic). 1943;71(4):582. doi:10.1001/archinte.1943.00210040141018

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In this monograph Zondek and Sulman present a rather full discussion of the problem of the antigonadotropic problem. They not only include a review of the literature but describe a few unpublished observations of their own. The data are divided and discussed as follows: "Historical Review," "The Antihormone Theory of Collip," "The Antigonadotropic Factor," "Clinical Significance of the 'Antihormones' " and "Mechanism of the Antigonadotropic Reaction." The authors present evidence which they believe strongly indicates that the antigonadotropic substances are to be classified "as a group of immune bodies of a character hitherto unknown in serology."

The monograph should be of great interest not only to persons interested in endocrinology, but to physiologists, biochemists, immunologists and internists. It tends to emphasize the immunologic mechanisms of antigonadotropic activity instead of the point of view that an antagonistic hormone is secreted that neutralizes gonadotropic substances. Many aspects of this problem, obviously, will remain

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