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Coca believes he has been able to delimit a group of cases of food allergy which differs in several respects from atopic ("reaginic") allergy: Allergic reagins or antibodies are not demonstrable by direct or indirect cutaneous testing; the hereditary influence controlling the occurrence of this type of allergy is independent of the atopic inheritance; many of the symptoms are not represented in the atopic group, and the allergic reaction practically always causes acceleration of the pulse. The symptoms of patients with such allergy are of extremely wide scope, ranging from physical fatigue to heartburn. Thus, their conditions comprise a wider range of ailments than is customarily accepted as being allergic in origin. Coca considers it possible in most instances to determine by means of the pulse rate all offending foods and other excitants with a high degree of accuracy. The method consists of establishing the basal pulse rate and its
Familial Nonreaginic Food-Allergy. Arch Intern Med (Chic). 1943;71(4):582. doi:10.1001/archinte.1943.00210040141019
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