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May 1943


Author Affiliations


From the Medical Service of Dr. George Baehr and the Department of Chemistry, Laboratories of the Mount Sinai Hospital.

Arch Intern Med (Chic). 1943;71(5):630-649. doi:10.1001/archinte.1943.00210050050005

GENERAL CONSIDERATIONS  In 1891 Recklinghausen1a described a curious disease of bone characterized by destruction and repair, marked softening of the bones and the presence of odd cysts. He recognized the similarity of his cases to that described by Engel1b some twenty-seven years previously. Recklinghausen was not aware of any endocrine disorder associated with the bony changes which he described. As a matter of fact, during the course of the next number of years many pathologists2 noted tumors of the parathyroid glands in the presence of certain kinds of bone disease but failed to grasp the etiologic relationship between the two. Erdheim3 was probably the first to recognize more than a casual relationship between the bony changes and the hyperplasia of the parathyroid glands in cases of osteomalacia, although his explanation of the observed phenomena later proved to be inadequate. It is easy to understand the early