Clinical investigations of the biology of syphilitic infection have been directed essentially to the elucidation of the problems of diagnosis, therapy and its complications, end results and serology. By its very nature, the clinical approach has been practically limited to the study of the disease in the viable host, and as a result many tangential issues have received no more than cursory and scattered attention. It is apparent that the coordination and correlation of the clinical aspects of the disease with the observations at autopsy will throw light on many problems which are still in the penumbra of knowledge. How frequently do persons with clinically diagnosed syphilis present morphologic evidence of syphilis at autopsy? What is the relationship between clinical cure and morphologic lesions at death? How often does a person with clinically diagnosed syphilis die as a direct result of his disease, and how often is the disease a
ROSAHN PD, BLACK-SCHAFFER B. STUDIES IN SYPHILIS: I. REVIEW OF THE INCIDENCE OF SYPHILIS IN AUTOPSIES ON ADULTS. Arch Intern Med (Chic). 1943;72(1):78–90. doi:10.1001/archinte.1943.00210070086008
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