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Article
July 1943

NITROGEN EQUILIBRIUM AND REGENERATION OF SERUM PROTEIN: FOLLOWING INTRAVENOUS USE OF AMINO ACIDS

Author Affiliations

NEW YORK

From the Third (New York University) Medical Division, Welfare Hospital for Chronic Diseases, and the Department of Medicine, New York University College of Medicine.

Arch Intern Med (Chic). 1943;72(1):91-103. doi:10.1001/archinte.1943.00210070099009
Abstract

Attention to nitrogen balance and the level of the blood proteins has of late years come to be recognized as an important part of preoperative and postoperative care1 in cases of diseases of the liver2 and biliary tract,3 of severe burns4 and of shock.5 A variety of substances have been used as sources of nitrogen. In shock, the necessity of obtaining immediate increase in osmotic pressure of the serum to prevent hemoconcentration makes human plasma and serum of undisputed importance, since simply by giving them one places proteins in circulation. The protein is in addition available for use by the body for maintaining nitrogen equilibrium and building new serum protein. The cost of collection and preparation of human plasma and serum is considerable, and for this reason Wangensteen and his co-wokers6 have attempted to use beef plasma as a substitute, with some degree of success. Solutions of

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