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July 1943

Vascular Spasm: Experimental Studies.

Arch Intern Med (Chic). 1943;72(1):146. doi:10.1001/archinte.1943.00210070154014

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Nedzel presents a summary of his experimental work on vascular spasm. He believes that a great number of diseases are due to disturbances brought about in an organ as a result of vascular spasm. Following the spasm of blood vessels, there results anoxia with associated local disturbances in metabolism and if prolonged permanent physiologic and anatomic damage. Endocarditis, gastric ulcer and multiple sclerosis are among the disease states discussed. The author presents evidence of having produced these states, or their equivalents, in experimental animals by vasospasm, pitressin having been the vasconstricting agent used.

The reviewer is impressed by the lack of thoroughness of control studies and the rather sweeping clinical implications made as a result of artificial experimental observations. Graphs are presented in the chapter entitled "Splanchno-Peripheral Balance" to show how application of cold to the surface of the body produces a decrease in the temperature of the viscera and

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