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Article
September 1943

VASCULAR DISEASE FOLLOWING TOXEMIA OF PREGNANCY (PREECLAMPSIA AND ECLAMPSIA): OBSERVATIONS ON ITS CLINICAL COURSE

Author Affiliations

BOSTON

From the Medical Clinic of the Peter Bent Brigham Hospital and the Department of Medicine, Harvard Medical School.

Arch Intern Med (Chic). 1943;72(3):301-318. doi:10.1001/archinte.1943.00210090002001
Abstract

Most studies of persistent hypertension following toxemia of pregnancy have been of a statistical nature. We are not familiar with any work that describes in detail the clinical course. It is our purpose to do this in the hope that it will provide a better understanding of the nature and importance of this disease and stimulate others to amplify our observations. As we shall see, the clinical analogy of toxemia of pregnancy and its late effects to acute glomerulonephritis and its sequelae is striking despite a distinct difference in the etiologic and the pathologic aspects of the two diseases. It will, perhaps, be convenient to bear in mind this analogy in considering the material to be presented. It must be emphasized, however, that the two diseases are different etiologically and pathologically.

In this report we have confined our studies to cases in which toxemia of pregnancy was imposed on a

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