In a previous paper we1 presented a modified technic for the determination of serum bilirubin. This technic possesses several technical advantages over the methods commonly in use and gives a more accurate evaluation of the concentration of the pigment. Furthermore, by this method the direct and indirect fractions can be measured separately. In this paper the results obtained from the clinical application of the new technic will be presented.
The method was used in a study of the behavior of the serum bilirubin of four different groups of persons: (1) normal persons and patients without evidence of hepatic disease; (2) patients who had hepatic disease but no jaundice; (3) patients in whose cases the result of the determination of the concentration of serum bilirubin and the result of the bromsulfalein test of hepatic function did not agree as to the presence of probable or proved hepatic disease and (4)
SEPULVEDA B, OSTERBERG AE. A MODIFIED TECHNIC FOR THE DETERMINATION OF SERUM BILIRUBIN: A PRELIMINARY REPORT OF ITS CLINICAL USE. Arch Intern Med (Chic). 1943;72(3):372–376. doi:10.1001/archinte.1943.00210090073006
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