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October 1943


Author Affiliations


From the Department of Comparative Pathology and Tropical Medicine, Harvard Medical School, and the National Institute of Hygiene and Public Health, Lima, Peru.

Arch Intern Med (Chic). 1943;72(4):429-438. doi:10.1001/archinte.1943.00210100002001

No specific treatment has as yet been developed for Oroya fever, the severe and often fatal anemic stage of Carrión's disease. There have been from time to time numerous attempts at immune therapy with serum or transfusions of whole blood from patients convalescing or recovered from various stages of Carrión's disease.1 There have undoubtedly been many more trials at therapy along these lines than have been published. The few reports available, however, are inconclusive and neither substantiate nor detract from the possibility that such forms of passive immunization may be beneficial in certain cases.

In the field of chemotherapy, arsenical preparations have been tried by certain investigators2; but the evidence for any consistent success in this direction has been entirely unconvincing.

The present communication deals with 3 cases of Oroya fever in which hyperimmune rabbit serum containing a high titer of agglutinins for Bartonella bacilliformis was given in