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Article
October 1943

CHANGES IN OPTIC FUNCTION AND OPHTHALMOSCOPIC PICTURE: OBSERVED IN FOUR PATIENTS OF THE EUNUCHOID SKELETAL TYPE WHO WERE BEING TREATED WITH AN ORCHIC EXTRACT

Author Affiliations

NEW YORK

From the Medical Clinic of the New York Polyclinic Medical School and Hospital.

Arch Intern Med (Chic). 1943;72(4):461-470. doi:10.1001/archinte.1943.00210100034003
Abstract

In 1922 Stanley,1 reporting on implantations of testicular substance, cited greatly strengthened vision in 32 of 41 inmates at San Quentin Prison who had previously complained of poor vision that necessitated glasses.

My interest in orchic extract therapy was aroused by its use in the case of a man who presented the conditions of eunuchoidism and pituitary tumor with changes in the fundi and impairment of optic function. After three months of therapy the ophthalmoscopic picture showed definite improvement. This observation led to the use of this extract in the treatment of 3 other patients of the eunuchoid skeletal type, all of whom were found to have changes in the fundi and impairment of optic function. The serial changes in the ophthalmoscopic picture were observed in the 4 patients so treated, for periods varying from seventeen months to two and one-half years. The cases are reported for their suggestive

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