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Article
March 1944

GROUP A HEMOLYTIC STREPTOCOCCUS ANTIBODIES: III. A STUDY OF THE SIMULTANEOUS INFECTION OF A LARGE NUMBER OF MEN BY A SINGLE TYPE

Arch Intern Med (Chic). 1944;73(3):238-240. doi:10.1001/archinte.1944.00210150041006
Abstract

It is well known that varying amounts of circulating antibacterial and antitoxic antibodies are present in the serums of many persons, that increases in these immune substances may be expected to occur following infections and that the magnitude of the immune response differs from individual to individual. Rarely, if ever, have actual measurements of these antibodies been made for large groups of human subjects simultaneously infected with a single strain of micro-organism.

An unusual opportunity to perform such studies became available recently when an outbreak of streptococcic pharyngitis occurred in an Army camp. Many of the clinical details of this epidemic have been described elsewhere,1 but they may be summarized here. Within sixty hours more than 300 men were admitted to the hospital suffering from typical hemolytic streptococcus tonsillitis or pharyngitis of varying degrees of severity. Approximately 20 per cent of them had a rash and presented the clinical

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