GRANULOCYTOPENIA AND AGRANULOCYTOSIS
—One case of osteopetrosis and 17 cases of myelofibrosis are reported by N. Rosenthal and Erf,358 with a discussion of the clinical and hematologic features and differential diagnosis of these conditions. Osteopetrosis occurs most often in childhood and is commonly associated with congenital abnormalities, mental retardation and usually enlargement of the liver and spleen. There is a generalized condensation of bone. Anemia is progressive and is usually associated with thrombopenia and leukopenia. Often immature cells of the myeloid series are seen in the peripheral blood. Myelofibrosis was first described by Hueck in 1879; since then approximately 75 cases have been reported. The diagnosis of the condition is generally made at autopsy. The clinical features include weakness, dyspnea, refractory anemia, splenomegaly, periostitis and pains in the bones. Myelofibrosis is observed equally often in the two sexes and has no predilection for
BETHELL FH, STURGIS CC, MALLERY OT, RUNDLES RW. BLOOD: A REVIEW OF THE RECENT LITERATURE. Arch Intern Med (Chic). 1944;74(3):197–233. doi:10.1001/archinte.1944.00210210044006
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