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November 1944


Arch Intern Med (Chic). 1944;74(5):384-389. doi:10.1001/archinte.1944.00210230076008

In the investigation of the problems of generalized amyloidosis we have had ample opportunity to study the development of adrenal amyloidosis. To correlate the clinical signs and symptoms which might be due to adrenal insufficiency with the degree of adrenal amyloidosis and to determine what metabolic studies may be useful in differentiating generalized amyloidosis, adrenal amyloidosis and the underlying disease producing amyloidosis is the purpose of these observations.

MATERIAL AND METHOD  During the past eleven years there were 468 cases of generalized amyloidosis at Sea View Hospital in 449 of which gross and microscopic examinations of the adrenals were made. In all but 7 patients (1 with bronchiectasis, 1 with syphilis and 5 with pulmonary abscesses), the underlying disease was tuberculosis. In 354 (81 per cent) of the patients the adrenal glands showed amyloidosis. Rosenblatt1 reported adrenal amyloidosis in 40 per cent of his patients with generalized amyloidosis; Bronfin