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Article
February 1945

ADENOMA OF THE ISLETS OF LANGERHANS WITH HYPOGLYCEMIA: REPORT OF TWO CASES

Author Affiliations

Associate Professor of Medicine; BLUEFIELD, W. VA.

From the Department of Medicine, Medical College of Virginia.

Arch Intern Med (Chic). 1945;75(2):109-118. doi:10.1001/archinte.1945.00210260037005
Abstract

Hyperinsulinism is a broad general subject, touching on the fields of endocrinology, carbohydrate metabolism and neuropsychiatry. Furthermore, this condition presents itself in all degrees of intensity. Functional hyperinsulinism with mild hypoglycemic symptoms arising between meals or following mild exercise is common, but functioning tumors of the pancreatic islet tissue are uncommon, and even less common are growths which have been successfully removed at operation. These small adenomas of the islets of Langerhans produce recurrent severe hypoglycemic reactions, which at first yield to progressive increases of the intake of carbohydrates, but are finally cured only by the surgical removal of the adenoma. The present is a report of 2 cases of adenoma of the islets of Langerhans in which the tumors were removed surgically, with successful control after operation.

REPORT OF CASES 

Case 1. 

History.  — The patient, a single white woman 24 years of age, was born and reared in

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