Rather extensive literature is accumulating on therapy for tularemia. Among the numerous agents used for the treatment of tularemia, several have received special mention. These are: (1) serum, (2) sulfonamide compounds, (3) arsenic compounds, (4) ferrous iodide, (5) metaphen and (6) acriflavine.
In brief résumé, the first of these, serum, has had the most extensive trials both clinically and experimentally. Unfortunately the work of Foshay1 in clinical trials and of Francis and Felton2 in experimental trials has led to opposing conclusions. The data which Foshay obtained from treating human beings led him to believe that serum effects a significant reduction in both morbidity and mortality. Francis and Felton, on the other hand, concluded that antitularemic serums prepared from horses, sheep and rabbits as well as from convalescent human beings show no evidence of protective effect in white mice.
Many other clinicians have reported on the use of serum
BELL JF, KAHN OB. EFFICACY OF SOME DRUGS AND BIOLOGIC PREPARATIONS AS THERAPEUTIC AGENTS FOR TULAREMIA. Arch Intern Med (Chic). 1945;75(3):155–158. doi:10.1001/archinte.1945.00210270012003
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