[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 18.207.129.82. Please contact the publisher to request reinstatement.
Article
March 1945

EFFICACY OF SOME DRUGS AND BIOLOGIC PREPARATIONS AS THERAPEUTIC AGENTS FOR TULAREMIA

Author Affiliations

DETROIT

Alexander Blain Hospital Research Associate in Pathology, Wayne University College of Medicine, Detroit.

Arch Intern Med (Chic). 1945;75(3):155-158. doi:10.1001/archinte.1945.00210270012003
Abstract

Rather extensive literature is accumulating on therapy for tularemia. Among the numerous agents used for the treatment of tularemia, several have received special mention. These are: (1) serum, (2) sulfonamide compounds, (3) arsenic compounds, (4) ferrous iodide, (5) metaphen and (6) acriflavine.

In brief résumé, the first of these, serum, has had the most extensive trials both clinically and experimentally. Unfortunately the work of Foshay1 in clinical trials and of Francis and Felton2 in experimental trials has led to opposing conclusions. The data which Foshay obtained from treating human beings led him to believe that serum effects a significant reduction in both morbidity and mortality. Francis and Felton, on the other hand, concluded that antitularemic serums prepared from horses, sheep and rabbits as well as from convalescent human beings show no evidence of protective effect in white mice.

Many other clinicians have reported on the use of serum

×