The nineteen-twenties will go down in medical history as the decade of two great therapeutic discoveries. Barely four years had elapsed since Banting's epochal discovery of insulin when Minot and Murphy1 startled the world by their announcement of the effect of liver on the course of pernicious anemia. The groundwork for this discovery was laid earlier by the studies of Whipple and his associates2 on the effect of a diet rich in red meat and liver on erythrocytopoietic activity in dogs with experimentally produced anemia.
The next important step in the progress of liver therapy was the preparation of an active liver extract which could be administered either by mouth or parenterally. This overcame the objections of many patients to the monotony of a daily diet including liver.
With the value of liver therapy firmly established, two questions occupied the minds of investigators: 1. What is the nature
SOKAL HB. EFFECTS OF SOME LIVER EXTRACTS ON THE CARBOHYDRATE METABOLISM. Arch Intern Med (Chic). 1945;75(5):324–326. doi:10.1001/archinte.1945.00210290047003
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