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Article
June 1945

INFECTIOUS MONONUCLEOSIS: AN ANALYSIS OF THREE HUNDRED CASES WITH THREE CHARACTERIZED BY RARE HEMATOLOGIC FEATURES

Author Affiliations

MEDICAL CORPS, ARMY OF THE UNITED STATES

Arch Intern Med (Chic). 1945;75(6):376-380. doi:10.1001/archinte.1945.00210300022002
Abstract

The variegated clinical manifestations of infectious mononucleosis have been emphasized repeatedly by most writers on the subject in recent years.1 It has also been emphasized that these manifold signs and symptoms often make the diagnosis difficult, because frequently some particular combination of symptoms of the disease will duplicate the important findings of other clinical entities.

We have reviewed a series of 300 cases of infectious mononucleosis observed over the past twenty months at several large air force hospitals, and we also have encountered the same long list of heterogeneous symptoms and signs that have been observed and recorded by other investigators. Moreover, we find that the relative frequency of these manifestations, with but insignificant percentage variations, closely approximates that observed by previous authors. In addition, however, to these manifestations, we have observed in this series 3 cases characterized by a severe anemia with leukopenia and thrombopenia which presented considerable

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