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Article
July 1945

STUDIES ON HYPERTENSION: IV. BIOASSAY OF VASOCONSTRICTOR SUBSTANCES IN ULTRAFILTRATES OF CITRATED BLOOD PLASMA FROM PATIENTS WITH NORMAL BLOOD PRESSURES, PATIENTS WITH ESSENTIAL HYPERTENSION AND PATIENTS MADE HYPERTENSIVE BY INTRAVENOUS INJECTIONS OF ANGIOTONIN (HYPERTENSIN)

Author Affiliations

GALVESTON, TEXAS

From the Departments of Internal Medicine and Pharmacology, University of Texas School of Medicine, Galveston, Texas.

Arch Intern Med (Chic). 1945;76(1):11-21. doi:10.1001/archinte.1945.00210310019002
Abstract

Since the results of previous investigations1 did not support the humoral origin of essential hypertension, it was concluded1c that "Final proof awaits conclusive demonstration of the presence or absence of angiotonin in increased amounts in the blood of patients with essential hypertension."

This report deals with a study of whether vasoconstrictor substances are present in increased amounts in the blood of patients with hypertension. The conclusion has been sought through a biologic assay of vasoconstrictor substances in the blood of patients with normal blood pressures, the blood of hypertensive patients and the blood of patients made transiently hypertensive by intravenous injections of angiotonin. There are conflicting reports in the literature regarding the presence of pressor compounds in the blood of hypertensive patients or in the blood of animals made hypertensive by renal ischemia. Danzer, Brody and Miles2 reported that the blood of patients with hypertension contained a pressor

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