Clinicians interested in infectious disease are aware that the exposure of a group of human beings or animals to an infectious agent will be followed by the development of clinical syndromes of varying degrees of severity. It is rarely possible to describe these phenomena in detail in human beings, since artificial inoculation is infrequently performed and since natural infection is usually unsuitable because the size of the infecting dose and the strain of microorganism may be expected to vary from case to case. These difficulties are particularly evident in the study of group A hemolytic streptococcus infections, since many serologic types are known to occur among these organisms.
One of us has previously described1 certain clinical and immunologic aspects of the disease resulting from the simultaneous infection of a large group of men by a single type of hemolytic streptococcus. Clinical observations in that epidemic were incomplete. Recently another
RANTZ LA, SPINK WW, BOISVERT PJ. HEMOLYTIC STREPTOCOCCUS SORE THROATDETAILED STUDY OF THE SIMULTANEOUS INFECTION OF A LARGE NUMBER OF MEN BY A SINGLE TYPE. Arch Intern Med (Chic). 1945;76(5):278–283. doi:10.1001/archinte.1945.00210350024004
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