The principal observations generally reported concerning persons with tumors of the adrenal cortex consist of obesity, purple striae of the skin, acne, polycythemia,is, imbalanceplasma electrolytes, diabetes, hypertension genital dystrophy. These signs and symptoms have been observed in persons with adenohyperplasiasin those with carcinomas of the adrenal cortex, and the total picture is usually referred to as Cushing's disease or adrenogenital syndrome. In general, even the benign tumors which produce this clinical entity occupy a large portion of the adrenal gland. There are, in addition, as Kepler and Keating1 pointed out, a large number of small cortical adenomasre encountereddentally in the course of routine autopsiespersons in whom there was no apparent clinical evidence of endocrine disease during life. The investigations presented here were undertaken in order to determine whether or not an examination of the clinical and pathologic data, in retrospect, would show the presence of certain endocrinologie disturbances not noted during the
RUSSI S, BLUMENTHAL HT, GRAY SH. SMALL ADENOMAS OF THE ADRENAL CORTEX IN HYPERTENSION AND DIABETES. Arch Intern Med (Chic). 1945;76(5):284–291. doi:10.1001/archinte.1945.00210350030005
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