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January 1946

BLOOD: A Review of the Recent Literature

Author Affiliations


Arch Intern Med (Chic). 1946;77(1):80-119. doi:10.1001/archinte.1946.00210360085006

INFECTIOUS MONONUCLEOSIS  AN increasing number of papers are appearing in the literature dealing with infectious mononucleosis, which is a malady of unusual interest chiefly because of its tendency to simulate so many other disease syndromes with its diverse symptoms, because there is still considerable doubt concerning its causation and its pathologic changes and because of the unique presence of sheep cell agglutinins in the blood of patients with this disease.Attempts have been made by Julianelle, Bierbaum and Moore215 to transmit infectious mononucleosis to rabbits and monkeys and, to a lesser extent, to white mice, guinea pigs and human beings. Specimens of blood were withdrawn from 15 patients during the febrile stage, on the second to the seventh day after the onset, except in 1 instance in which the collection was made on the tenth day of illness, after two days of normal temperature. Experiments