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February 1946

ATYPICAL HEMOLYTIC ANEMIA: Observations with Particular Reference to the Use of Transfusions in the Study of Hemolytic Mechanisms

Author Affiliations


From the Department of Medicine, University of Rochester School of Medicine and Dentistry, and the Medical Clinic of the Strong Memorial Hospital.

Arch Intern Med (Chic). 1946;77(2):151-178. doi:10.1001/archinte.1946.00210370032004

TWO unusual cases of hemolytic anemia recently studied in the Strong Memorial Hospital presented excellent opportunities for exploring the usefulness of transfusion experiments in the investigation of hemolytic mechanisms.

As a matter of additional interest, the serum of the first patient contained autohemagglutinins active against human cells of all types at body temperature and a1 agglutinins, active against A1 cells only. The latter agglutinins have been described in detail in a separate paper1 devoted to blood subgroups. Some of the features of the second case have also been presented in another publication,2 which dealt with the in vivo maturation and destruction of the patient's reticulocytes after transfusion to a small child. It has been amply demonstrated by means of the Ashby technic3 and its various modifications4 that transfused normal erythrocytes in the circulation of compatible "normal" recipients disappear in a linear fashion over a period of one

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