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July 1946

PLASMA QUINACRINE CONCENTRATION AS A FUNCTION OF DOSAGE AND ENVIRONMENTJoint Report of the Armored Medical Research Laboratory, Fort Knox, Ky., and the Commission on Tropical Diseases, Army Epidemiological Board, Preventive Medicine Service, Office of The Surgeon General, United States Army

Arch Intern Med (Chic). 1946;78(1):64-107. doi:10.1001/archinte.1946.00220010074007

INTRODUCTION  THIS report deals with a study1 carried out at the Armored Medical Research Laboratory as a part of the program of the Commission on Tropical Diseases of the Surgeon General's Office for the investigation of quinacrine hydrochloride (atabrine) therapy. The primary purposes of the study were: (1) to determine the plasma quinacrine levels in large groups of healthy young men on several suppressive regimens of the drug, (2) to determine the influence of a simulated jungle climate on plasma quinacrine concentrations, (3) to determine the effect of quinacrine on acclimatization and performance of men in humid heat and (4) to determine the plasma concentrations for therapeutic levels of quinacrine intake and relate these concentrations to the plasma concentrations of the same subjects on suppressive regimens. It was anticipated that such information, together with that which was already available,2 would facilitate the designing of regimens of quinacrine therapy

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