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October 1946

MEGAKARYOCYTIC REACTION LOCALIZED IN THE BONE MARROWReport of a New Hematologic Syndrome with Observations on the Origin and Development of Megakaryocytes and on the Derivation of Platelets

Arch Intern Med (Chic). 1946;78(4):387-404. doi:10.1001/archinte.1946.00220040021002

HITHERTO there have been only two diseases known in which he megakaryocytes occupy the center of the pathologic picture. One is thrombopenic purpura, in which these cells suffer an injury. The other is chronic aleukemic myelosis, characterized by an extramedullary megakaryopoiesis. A case of acute megakaryoblastic leukemia, the only one so far recorded in the literature, was described by von Boros.1 However, its authenticity is doubted by some hematologists.2 In other lesions in which these bone marrow cells are involved, such as in chronic myeloid leukemia, hyperthyroidism and polycythemia, they merely play a secondary role.

In the present case the megakaryocytes were the elements affected principally and in a manner unique in hematologic history. It is reported, also, because of the light it throws on the problems concerning the origin and maturation of megakaryocytes and the derivation of platelets from them.


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