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Article
October 1946

INFECTIOUS DISEASESTwelfth Annual Review of Significant Publications

Arch Intern Med (Chic). 1946;78(4):447-494. doi:10.1001/archinte.1946.00220040081006
Abstract

THE RESULTS of continued research on antibiotic agents and their practical application hold the chief interest in the field of infectious diseases. Much knowledge has accrued concerning the value of penicillin, streptomycin and other agents when used in the treatment of certain infections and their lack of effect when used in the treatment of others. Intensive investigation of the chemical structure of antibiotics and development of better methods for their commercial production are in progress. The use of penicillin to combat many serious infections, such as the bacterial pneumonias, infections with hemolytic streptococci and subacute bacterial endocarditis, has brought about a great reduction in their incidence and mortality rate. The mortality from degenerative cardiac, renal and other diseases has also declined as a result of the control of incidental infections, which commonly cause death in such patients.1 This decline, however, has been continuous for many

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