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Article
April 1947

TREATMENT OF PLASMODIUM VIVAX MALARIA OF FOREIGN ORIGIN: A Comparison of Various Drugs

Arch Intern Med (Chic). 1947;79(4):365-380. doi:10.1001/archinte.1947.00220100015001
Abstract

IT IS THE purpose of this report to present data concerning the efficacy of various drugs in the treatment of Plasmodium vivax malaria of imported origin. Observations were made on the use of quinacrine hydrochloride (atabrine), quinine sulfate and three drugs known as SN 6911 (3-methyl-4-[4-diethylamino-1-methylbutylamino]-7-chloroquinoline), chloroquine and SN 8137 (4-[3-diethylamino-2hydroxypropylamino]-7-chloroquinoline).1 Data on the immediate response to therapy and minor toxic symptoms after the use of all drugs and on the rates of relapse following administration of quinacrine hydrochloride, SN 6911 and chloroquine will be presented in this paper. A separate report will be presented of laboratory studies, including plasma drug concentrations, tests of hepatic function and hematologic and urinary examinations.2 Some of the data on the patients given quinacrine hydrochloride and quinine sulfate have been included in another report comparing these two commonly used antimalarial drugs.3

SUBJECTS AND METHODS  All the subjects were white soldiers who had

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