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March 1948

CARDIOVASCULAR DISEASESA Review of Significant Publications From January 1944 to June 1947

Author Affiliations

With the Editorial Assistance of EDWARD F. BLAND, M.D.; BOSTON

Arch Intern Med (Chic). 1948;81(3):397-419. doi:10.1001/archinte.1948.00220210151014

CORONARY HEART DISEASE  The predilection of atherosclerosis for the coronary arteries is the subject of a paper by Dock126 which provides much food for thought. Dock points out that atheromatosis may be limited to the coronary arteries, without evident involvement of other portions of the vascular system and that this is the rule in coronary heart disease in men under 40. He discusses the role of hypercholesteremia, pointing out that there is a high incidence of coronary artery disease in congenital xanthomatosis and also in other conditions in which there is a high blood cholesterol level, as in obesity, diabetes mellitus and myxedema. He also refers to the possibility that the increased incidence of myocardial infarction in hypertensive persons may be due to the greater oxygen needs of the left ventricle as well as to a greater severity of atherosclerosis. In his studies of the

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