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May 1948

FOOD PROTEIN CONSUMPTION IN GLOMERULONEPHRITIS: Effect on Proteinuria and the Concentration of Serum Protein

Author Affiliations


From the Department of Medicine, Stanford University School of Medicine, San Francisco.

Arch Intern Med (Chic). 1948;81(5):612-622. doi:10.1001/archinte.1948.00220230010002

WITHIN the last decade, few studies have been made of the relationship of consumption of food protein to proteinuria and to concentration of serum protein in glomerular nephritis, although previously many such reports appeared in the literature. Additions to the knowledge of renal pathophysiology during this period, however, offer explanations for phenomena previously unexplained, and contradict some interpretations which have been offered in the past. Certain objections now may be made to the technic employed in some of the older investigations. The therapeutic corollary to this relationship still remains a source for controversy, but much evidence has accumulated to show that attempts at treatment with high protein diets in conditions associated with renal damage may not be helpful, as was previously supposed by some, but may be dangerous. For these reasons, the following experiments were undertaken to demonstrate the effect of varying levels of consumption of food protein on proteinuria

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