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Article
May 1948

CIRRHOSIS FOLLOWING INFECTIOUS HEPATITISA Report of Five Cases, in Two of Which There Was Superimposed Primary Liver Cell Carcinoma

Arch Intern Med (Chic). 1948;81(5):666-689. doi:10.1001/archinte.1948.00220230064006
Abstract

IN AN APPRECIABLE number of cases infectious hepatitis leaves clinical evidence of impaired hepatic function and in some instances manifests itself as a chronic, probably progressive, disease. We believe that in some cases the morphologic pattern of its late stages is distinct, although its clinical course is indistinguishable from that of Laennec's cirrhosis or acute hepatic failure.

In this report we present 5 cases in which cirrhosis, we believe, resulted from infectious hepatitis. Primary liver cell carcinoma developed in 2 of these. In 4 the cirrhosis was clinically indistinguishable from Laennec's cirrhosis; the morphologic findings ruled out this diagnosis, and the fundamental lesion of the liver was identical with that described by F. B. Mallory as "toxic cirrhosis." Our few cases, however, do not preclude types of lesions other than that reported here as end results of infectious hepatitis.

Observations concerning the outcome of infectious hepatitis have resulted in two

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