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Article
May 1948

MASSIVE PICROTOXIN THERAPY IN TREATMENT OF ACUTE BARBITURATE POISONING

Arch Intern Med (Chic). 1948;81(5):690-695. doi:10.1001/archinte.1948.00220230088007
Abstract

THE PURPOSE of this presentation is to describe our experience in the treatment of acute barbiturate intoxication with massive doses of picrotoxin in 30 cases. These cases were seen since Jan 1, 1946.

The treatment of barbiturate poisoning has been extensively discussed in the literature with various therapeutic procedures recommended, depending on the drug of choice. We have selected 11 severe cases from our series to demonstrate the massive therapy employed. In 2 of the selected cases doses of picrotoxin greater than any previously recorded in the literature were given.1

It is usually difficult to determine the amount of barbiturate consumed and the time elapsed before hospitalization, so that the severity of the poisoning must be judged from the initial observations and the subsequent course. We considered intoxication to be severe: (1) when more than 1 to 2 Gm. of a barbiturate was ingested; (2) when unconsciousness prior to hospitalization

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