—In studies by Cantoni and Eastman304 on the responsiveness of the isolated guinea pig intestine, maximal contractions obtained in response to a large dose of histamine, acetylcholine, pilocarpine, barium chloride and "mecholyl chloride" were followed by temporary depression. On the other hand, a maximal contraction in response to large doses of potassium chloride did not result in a decreased contractility. A small increase in the potassium-calcium ratio of the perfusion fluid, such as is obtained by doubling the potassium content of Tyrode solution, was sufficient to neutralize the effect of large doses of histamine, acetylcholine, pilocarpine and barium chloride.B-dimethylaminoethyl benzilate hydrochloride abolished the activity of exteriorized loops of dog intestine to a degree commensurate with the dosage of the drug, peristalsis being inhibited somewhat longer than rhythmic segmentation.305 Dibutoline sulfate, a new synthetic antispasmodic drug, proved to be effective in
KIRSNER JB, PALMER WL, RICKETTS WE, DASHIELL GF, BUSER JW. GASTROENTEROLOGY: A Review of the Literature from July 1946 to July 1947. Arch Intern Med (Chic). 1948;81(5):746–790. doi:10.1001/archinte.1948.00220230144009
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